Table 4 Incidence density and hazard ratios of fibromyalgia for iron deficiency anemia status combined with therapy (including iron supplementation and blood transfusion).

From: The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Variables

N

Event no

Person-year

Incidence density#

HR (95% CI)

Crude

Adjusted†

Crude

Adjusted†

Non-IDA group

13,381

3027

102,479

29.5

Ref

Ref

  

IDA group

Without therapy

5355

1445

33,119

43.6

1.45 (1.36–1.55)

1.38 (1.30–1.47)

Ref

Ref

Blood transfusion alone

694

116

3097

37.5

1.20 (0.99–1.44)

1.18 (0.98–1.43)

0.82 (0.68–0.99)

0.88 (0.73–1.07)

Iron supplementation alone

6777

1703

49,022

34.7

1.17 (1.10–1.24)

1.10 (1.03–1.16)

0.81 (0.75–0.87)

0.79 (0.73–0.85)

Combination of iron supplementation and blood transfusion

555

83

3404

24.4

0.80 (0.64–0.99)

0.73 (0.58–0.90)

0.55 (0.44–0.68)

0.54 (0.43–0.67)

  1. IDA iron deficiency anemia, HR hazard ratio, CI confidence interval.
  2. #Per 1000 person-years.
  3. †Model adjusted for sex, age, and each comorbidity (including diabetes, obesity, osteoarthritis, sleep disorder, irritable bowel syndrome, migraine, TMJ, depression, and anxiety).
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