Figure 4

Intravenous model of pNEN metastasis. (a) Average tumor growth rates as measured by log-transformed photon flux in Qgp1.luc and BON1.luc injected mice. p < 0.01 was obtained from linear mixed effects regression models on data for all mice (shown in b) to estimate and compare tumor growth curves. (b) Graphs showing individual tumor growth rates, as measured by in vivo BLI, in each NSG mouse following intravenous injection of Qgp1.luc cells (top, n = 10 mice) and BON1.luc cells (bottom, n = 13 mice). Each line reflects a single mouse with tumor growth quantified by total photon flux (photons per second) over the indicated time. (c) Longitudinal bioluminescence images at the indicated times in weeks post-injection with Qgp1.luc (top) and BON1.luc (bottom) cells. Each set of images was taken from the same mouse. (d) Average number of tumor foci per mouse in Qgp1.luc and BON1.luc animals based on quantified photon flux of tumors by ex vivo BLI. *, p < 0.01 by Students t-tests with equal variance comparing the number of tumors between cell types.