Figure 5
Sites and frequency of tumor distribution in the IV model. (a) Quantified distribution of bioluminescent pNEN cells per tissue by ex vivo BLI. All BON1.luc-injected mice (9 out of 9) exhibited lung tumors while most QGP1.luc-injected mice (7 of 8) exhibited liver tumors. (b) In vivo BLI of mice immediately following injection with Qgp1.luc and BON1.luc cells (Day 0). Three representative mice in each group are shown. (c) Representative H&E images of Qgp1.luc and BON1.luc tumors that colonized the liver and lung, as indicated. The liver in a representative BON1.luc mouse shows no tumors in that tissue. (d) IHC staining (brown) for the NEN marker, synaptophysin, on the same tissues shown in (c).
