Table 1 Characteristics of the selected randomized controlled trials.

From: Ultrasound-guided corticosteroid injection for patients with carpal tunnel syndrome: a systematic review and meta-analysis of randomized controlled trials

Author, year

Corticosteroid

Intervention group (ultrasound-guided injection)

Control group (landmark-guided injection)

Outcome measures

Follow-up duration (weeks)

Plane of approach

n (hands)

Mean age (SD)

Mean symptom duration (weeks) (SD)

n (hands)

Mean age (SD)

Mean symptom duration (weeks) (SD)

Roh et al., 201933

Single 2-mL injection that contained 1 mL of lidocaine (10 mg/mL) and 1 mL of triamcinolone acetonide (20 mg/mL)

Out-of-plane ulnar approach

51

54 (35–64) (range)

15 (3–84) (range)

51

55 (37–66) (range)

14 (3–60) (range)

BCTQ (SSS, FSS)

24

Rayegani et al., 201934

1 mL of triamcinolone 40 mg plus to 1 mL of lidocaine 2%

In-plane ulnar approach

26

54.39 (9.3)

N/A

27

54.39 (9.3)

N/A

BCTQ (SSS, FSS) and electrodiagnostic findings (SNAP, CMAP)

10

Vahdatpour et al., 201932

Methylprednisolone acetate 40 mg without local anesthetics

In-plane ulnar approach

29

48.14 (9.41)

N/A

23

47.61 (8.30)

N/A

BCTQ (SSS, FSS) and electrodiagnostic findings (SNAP, CMAP)

12

Chen et al., 201831

Betamethasone 1 ml (Betamethasone 1 ml /amp, 1 ml contains betamethasone dipropionate 5 mg and betamethasone disodium phosphate 2 mg)

Out-of-plane ulnar approach

22

51.09 (10.09)

70.55 (70.61)

17

51.12 (8.19)

65.12 (63.03)

BCTQ (SSS, FSS) and electrodiagnostic findings (SNAP, SNCV, DML, CMAP)

72

Karaahmet et al., 201730

1 mL of betamethasone sodium phosphate (2.63 mg)/betamethasone dipropionate (6.43 mg)

In-plane ulnar approach

15

59.4 (12.4)

28.5 (30.6) Days

16

61.5 (10.3)

38.5 (40.4) Days

BCTQ (SSS, FSS) and electrodiagnostic findings (SNAP, SNCV, DML, CMAP)

4

Eslamian et al., 201729

40 mg of methylprednisolone without local anesthetic

In-plane ulnar approach

30

54.52 (2.05)

N/A

30

49.33 (1.82)

N/A

BCTQ (SSS, FSS) and electrodiagnostic findings (SNAP, SNCV, DML, CMAP)

12

Lee et al., 201428

1 mL of 40 mg/mL triamcinolone and 1 mL of 1% lidocaine

In-plane ulnar approach

26

55.2 (13.2)

8.9 (2.2)

15

50.3 (9.6)

7.6 (2.9)

BCTQ (SSS, FSS) and electrodiagnostic findings (DML, CMAP, DSL, SNAP)

12

Out-of-plane ulnar approach

24

52.6 (11.60

9.4 (3.6)

Ustün et al., 201327

40 mg of methylprednisolone

Out-of-plane ulnar approach

23

45.96 (10.49)

16.78 (10.65)

23

42.71 (11.38)

10.19 (10.19)

BCTQ (SSS, FSS)

12

  1. N/A not applicable, BCTQ Boston Carpal Tunnel Syndrome Questionnaire, SSS Symptom Severity Scale, FSS Functional Status Scale, SNAP sensory nerve action potential, CMAP compound muscle action potential, SNCV sensory nerve conduction velocity, DML distal motor latency, DSL distal sensory latency, SD standard deviation