Table 1 Patients’ characteristics.
From: Burden of critically ill patients with influenza in a French catchment population
2008 n = 5 | 2009 n = 40 | 2010 n = 41 | 2011 n = 40 | 2012 n = 75 | Total n = 201 | |
|---|---|---|---|---|---|---|
Epidemiology | ||||||
Age (years) | 67 ± 25 | 54 ± 14 | 57 ± 15 | 72 ± 13* | 65 ± 15* | 63 ± 16 |
Sex-ratio | 0* | 1.2 | 2.2 | 1.1 | 0.9 | 1.1 |
Influenza vaccination | 0 | 4 (10) | 5 (12) | 10 (25) | 6 (8.0) | 25 (12) |
Comorbidities | ||||||
None | 2 (40) | 9 (23) | 4 (10) | 2 (5.0)* | 2 (2.7)* | 19 (9.5) |
Type | ||||||
Chronic pulmonary disease | 0 | 10 (25) | 16 (39) | 19 (48) | 26 (35) | 71 (35) |
Chronic heart disease | 1 (20) | 7 (18) | 6 (15) | 8 (20) | 20 (27) | 42 (21) |
Renal insufficiency | 1 (20) | 6 (15) | 7 (17) | 2 (5.0) | 6 (8.0) | 22 (11) |
Immune depression | 2 (40) | 13 (33) | 12 (29) | 4 (10)* | 16 (21) | 47 (23) |
Pregnancy | 0 | 0 | 1 (2.4) | 0 | 1 (1.3) | 2 (1.0) |
Severe obesity | 0 | 6 (15) | 6 (15) | 5 (13) | 12 (17) | 29 (14) |
Life expectancy | ||||||
None or non-fatal | 2 (40) | 25 (63) | 26 (63) | 30 (75) | 42 (56) | 125 (62) |
Fatal within 5 years | 2 (40) | 12 (30) | 14 (34) | 9 (23) | 28 (37) | 65 (32) |
Fatal within 1 year | 1 (20) | 3 (7.5) | 1 (2.4) | 1 (2.5) | 5 (6.7) | 11 (5.5) |
ICU stay | ||||||
Symptom duration before ICU (days) | 8.8 ± 6.5 | 4.5 ± 3.2 | 5.6 ± 4.5 | 3.9 ± 4.0 | 5.6 ± 6.1 | 5.1 ± 5.0 |
Main reason for admission | ||||||
Respiratory distress | 5 (100) | 38 (95) | 35 (85) | 33 (83) | 63 (84) | 174 (87) |
Shock | 0 | 1 (2.5) | 4 (9.8) | 2 (5.0) | 6 (8.0) | 13 (6.5) |
Neurological failure | 0 | 1 (2.5) | 1 (2.4) | 2 (5.0) | 3 (4.0) | 7 (3.5) |
Other | 0 | 0 | 1 (2.4) | 3 (7.5) | 3 (4.0) | 7 (3.5) |
Bacterial coinfection at admission | 2 (40) | 7 (18) | 9 (22) | 14 (35) | 16 (21) | 48 (24) |
SAPS II | 48 ± 16 | 43 ± 19 | 44 ± 21 | 46 ± 16 | 43 ± 15 | 44 ± 17 |
SOFA score | 11 ± 3.7 | 8.0 ± 4.3 | 8.9 ± 5.1 | 10 ± 4.0* | 6.8 ± 3.7 | 8.3 ± 4.4 |
Evolution | ||||||
ARDS | 5 (100) | 25 (63) | 24 (59) | 25 (63) | 34 (45) | 113 (56) |
Mechanical ventilation | 5 (100) | 35 (88) | 37 (90) | 35 (88) | 67 (89) | 179 (89) |
ECMO | 0 | 5 (13) | 3 (7.3) | 0 | 0 | 8 (4.0) |
VAP | 1 (20) | 12 (30) | 8 (20) | 13 (33) | 17 (23) | 51 (25) |
Length of stay | ||||||
ICU (days) | 21 ± 29 | 22 ± 29 | 16 ± 24 | 17 ± 18 | 17 ± 22 | 18 ± 23 |
Hospital (days) | 32 ± 36 | 33 ± 30 | 34 ± 43 | 27 ± 22 | 39 ± 35 | 34 ± 34 |
Mortality | ||||||
Day 28 | 3 (60) | 10 (25) | 6 (15) | 8 (20) | 10 (13) | 37 (18) |
ICU | 3 (60) | 13 (33) | 7 (17) | 9 (23) | 11 (15) | 43 (21) |
In-hospital | 3 (60) | 13 (33) | 8 (20) | 13 (33) | 16 (21) | 53 (26) |
