Figure 5
From: Improved methods for RNAseq-based alternative splicing analysis
Aberrant splicing in uveal melanoma. (A) Boxplot comparing the number of splice event outliers between SF3B1 mutant patients (n = 18) and wild-type patients (n = 62) by splice event type. (B) Heatmap overview of differentially spliced events between SF3B1 mutant and wild-type tumors. Bins on the x-axis indicate the number of SF3B1 mutant tumors meeting the outlier criteria and bins on the y-axis indicate the Bisbee Diff LLR, and the color indicates the number of events falling into each bin. (C) Event type and protein level effects of events that are differentially spliced between SF3B1 mutant and wildtype tumors, are outliers in at least one SF3B1 mutant tumor, and result in an altered protein sequence.
