Figure 2 | Scientific Reports

Figure 2

From: Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

Figure 2

Necroptosis detection in human CCA primary tissues. (A) The representative membranous pMLKL immunostaining in primary CCA tissues. Black arrowheads indicate bile ducts and pMLKL positive staining. Four representative images obtained from four CCA patients with different pMLKL labeling index including 1. 92%, 2. 88%, 3. 65%, and 4. 39%, respectively. (B) The representative of positive signal (red dots) for RIPK1-RIPK3 interaction in primary CCA tissues using PLA assay. (C) The representative of double staining for pMLKL immunofluorescence staining and RIPK1-RIPK3 using PLA and in primary CCA tissues. White arrowheads indicate bile ducts and positive staining (D) The pMLKL and PLA (RIPK1-RIPK3) status of 5 selected CCA patients.

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