Figure 4 | Scientific Reports

Figure 4

From: Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

Figure 4

Differential associations of necroptosis activation and MLKL with inflammatory/immune cells infiltration. (A) Box plots showing the distributions of tumor-infiltrating CD8+ T cells, FOXp3+ T cells, and CD163+ M2 macrophages. (B) The correlation analysis of necroptosis activation (pMLKL) and MLKL with CD8+ T cells, FOXp3+ T cells, and CD163+ M2 macrophages. (C) Boxplot representing the relationship between the infiltration of CD8+ T cells in tumor central area and pMLKL positive staining (Mann–Whitney U-test). (D) Kaplan–Meier survival analysis of CCA patients divided by a favorable MLKL/immune signature (high CD8+ /high FOXp3+ /low CD163+ /low MLKL) and an unfavorable MLKL/immune signature (low CD8+ /low FOXp3+ /high CD163+ /high MLKL) for overall (OS) and disease-free (DFS) survival rates.

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