Figure 4
From: Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo
Ki67 proliferation index in xenograft tumors generated with miRNA constructs and comparison of cancer signature between these tumors and HCC cancer panels (i): Ki-67 expression ratio: Ki-67 positive cells per 100 cells obtained from tumor tissues transduced with scrambled control vector, miRNA-503i and miRNA-23ai. (ii): Comparing cancer signature between tumors developed in mice transduced with either miRNA-503i or miRNA-23ai using NTP method with FDR < 0.05 looking at known indicators of HCC. *CK-19: (cytokeratin-19). **S1–S3: (three robust HCC subclasses (termed S1, S2, and S3), each correlated with clinical parameters such as tumor size, extent of cellular differentiation, and serum alpha-fetoprotein levels. An analysis of the components of the signatures indicated that S1 reflected aberrant activation of the WNT signaling pathway, S2 was characterized by proliferation as well as MYC and AKT activation, and S3 was associated with hepatocyte differentiation. ***EpCAM: (epithelial cellular adhesion molecule). ****G3: (Glypican 3). VNTP method: Nearest-Template Prediction method (NTP, extensively reviewed, Hoshida Y. 2010).
