Figure 1 | Scientific Reports

Figure 1

From: G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis

Figure 1

GRK5 expression in human synovium. (A) Representative immunohistochemical staining for GRK5 in normal, OA, and RA synovium. RA synovium samples were divided into two groups due to subsynovial inflammatory infiltration; lymphocyte poor (RA-p) and rich (RA-r). Scale bar = 100 μm. (B,C) Quantification of GRK5-positive cells in the synovial (B) lining layer and (C) sublining layer of normal, OA, and RA synovium. Results are shown as percentages of cells positive for GRK5 from three normal donors, three OA donors, three RA-p donors, and three RA-r donors. Values are means ± SD. *P < 0.05; **P < 0.01 versus normal. (D,E) Representative immunofluorescence staining for GRK5, (D) Cadherin-11, and (E) CD68 in human RA synovium. Scale bar = 100 μm.

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