Figure 1
Establishment of PDX models from resected tumors. Pairs of patient primary-PDX tumors show a high overlap of histological features. (A) A poorly differentiated PDAC (OCIP88) with cords of infiltrating tumor cells. (B) An IPMN (OCIP250) with papillary growth lined by columnar and mucinous tumor cells. (C) An acinar cell carcinoma (OCIP270) showing tumor cells with eosinophilic cytoplasm growing in sheets. (D) An adenosquamous carcinoma (OCIP130) showing highly similar histological appearances in both the primary and PDX tumors. (E) A cholangiocarcinoma (OCIP194) with focal glandular structures. Scale bars are 300 μm. Histology images were color balanced to compensate for over-/under-staining, no features were altered in the process. (F) A significantly lower rate of overall survival (OS) was associated with patients’ tumors that had successful initial engraftment (XG at P0) compared to those that failed engraftment (No XG). A multivariate table shows analysis of variables with hazard ratio (HR). (G) Growths of individual pancreatic tumors to an average of 1.5 cm3 at humane endpoint, at the flank of NOD SCIDs.
