Table 1 The IC50 values (μM) of compounds 7a–o against urease.

From: Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors

Compound

R

IC50 (μM)a

7a

Phenyl

4.43 ± 0.21

7b

2-Hydroxyphenyl

3.09 ± 0.13

7c

2,4-Hydroxyphenyl

1.2 ± 0.05

7d

3,4,5-Trimethoxyphenyl

2.53 ± 0.11

7e

3-Phenoxyphenyl

2.85 ± 0.23

7f

4-Chlorophenyl

3.56 ± 0.16

7g

3-Boromophenyl

3.62 ± 0.19

7h

2-Nitrophenyl

0.61 ± 0.06

7i

4-Nitrophenyl

1.31 ± 0.09

7j

2,3-Dichlorophenyl

4.52 ± 0.31

7k

2-Chloro-5-nitrophenyl

3.94 ± 0.25

7l

2-Nitro-5-chlorophenyl

1.34 ± 0.12

7m

Thiophen-2-yl

0.86 ± 0.08

7n

5-Chlorothiophen-2-yl

4.56 ± 0.18

7o

Naphthalen-1-yl

1.94 ± 0.22

Hydroxyurea

–

100 ± 0.15

Thiourea

–

23 ± 1.7

  1. aValues are the mean ± standard error of the mean. All experiments were performed at least three times.
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