Figure 1
18F-FDG glucose uptake decreases in the ipsilateral striatum on days 1 and 3 after ICH. (a) Representative images of brain coronal slices show hematoma at different time points after collagenase-induced intracerebral hemorrhage (ICH). Brain slices were 1 mm thick. Scale bar: 500 µm. (b) Representative PET images of mice without (sham) or with ICH. Left panel: averaged PET images normalized to cerebellum (CB-ratio) for sham group and ICH group, fused with MRI reference template. Right panel: CB-ratio images fused with volume of interest (VOI) outlines to place brain regions. Red region shows nonspecific high activity area (blood in retro-orbital sinus). (c) Time activity curves (TAC) of striatum, cortex, and hippocampus (hippo) during 60 min of PET scanning on day 1 after ICH. n = 3. Each symbol represents the mean at that time point. (d, e) Average 18F-FDG standardized uptake value ratio (SUVR) at 40–60 min of PET scan on day 1 (d) and day 3 (e) after ICH. n = 9; #p < 0.05. Two-way ANOVA by hemisphere and brain region followed by Bonferroni post hoc test. Results are presented as box-and-whisker plots (the middle horizontal line within the box represents the median, boxes extend from the 25th to the 75th percentile, and the whiskers represent 95% confidence intervals).
