Figure 6
From: Entrapment of glucose oxidase within gold converts it to a general monosaccharide-oxidase
Suggested mechanism. Top left: Free GOx—fructose cannot enter the tunnel to reach active site. Bottom left: The interactions of the monomeric units of GOx with the gold, affect some separation of the monomeric units (exaggerated in the scheme for explanatory purposes), widening the tunnel, and allowing fructose to enter the relatively non-altered pair of active sites. (RCSB ID: 1GPE) Right: Asparaginase is a dimer of two pairs—colored in blue and silver—of tightly held dimers. Interactions of the outer surface as shown for GOx are similarly capable of opening the interface between the silver and blue dimers, easing the entrance (top arrow) of the “wrong” d-asparagine. (RCSB ID: 6EOK).
