Figure 5
From: Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model
The Mouse Grimace Scale score shown for male and female animals. Values 1, 3, 6, and 24 h after the procedure and the respective baseline (B) values from the day before are displayed. The number of observations for each time point is indicated as dots. Difficulties in obtaining high-quality images for scoring resulted in lower observation numbers than actual animal numbers at several time points. Bonferroni post hoc test detected no differences between the treatment groups at baseline measurements. In male mice, LiBupOP showed significantly higher MGS compared to other treatment groups at all post-procedure time points (p < 0.05). In female animals 1 h post-procedure, MGS was significantly lower in the LiBupOP group compared to the PaLiBupOP, PaOP, and PaAn groups. Pa showed significantly lower MGS at 1 h post-procedure compared to the PaLiBupOP and PaAn groups. At 3, 6 and 24 h post-procedure LiBupOP had a significantly lower MGS than all other treatment groups. Significant differences to the respective baseline measurements are indicated with *p ≤ 0.05, Dunnett’s post hoc. Data are shown as scatter dot plot with mean ± SD. Numbers per group: PaLiBupOP, LiBupOP, PaOP, and PaAn n = 10/per sex; Pa male n = 10, Pa female n = 8.
