Figure 8
From: Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model
Fecal corticosterone metabolites (ng/0.05 g feces) in baseline and post-procedure phase for male and female mice in each treatment group. FCMs were measured at the respective baseline time points and 1, 3, 6, and 24 h after surgery or anesthesia. The number of animals from which samples could be collected is indicated as dots. This number is lower than the actual animal number in several cases as feces could not be obtained from all animals. Bonferroni post hoc analysis detected no significant differences between the treatment groups at the baseline level. Male PaLiBupOP had a significantly higher FCM concentration than LiBupOP 6 h after surgery. In female animals, PaLiBupOP showed significantly higher FCM levels than LiBupOP 1, 6, and 24 h after surgery. At 24 h after surgery or anesthesia, female PaLiBupOP had significantly higher FCM levels than PaOP and PaAn, while FCM concentrations in LiBupOP were significantly lower than in PaOP. Significant differences to the respective baseline measurements are indicated with *p ≤ 0.05. Data are shown as scatter dot plot with mean ± SD. Numbers per group: PaLiBupOP, LiBupOP, PaOP, and PaAn n = 10/per sex.
