Figure 1

Immunohistochemical expression of Gal3ST1 in renal cell carcinoma. (a) cytoplasmatic and partially membranous positivity for Gal3ST1 could be observed in all common types of RCC. In this figure, Gal3ST1 expression in ccRCC and pRCC (type 1 and 2) was evaluated as highest intensity grade (IG = 3) and in shown ChRCC as IG = 1. (b) tumor-free kidney tissue typically shows physiological Gal3ST1 positivity of (proximal > distal) tubuli and negativity of glomeruli, interstitium and blood vessels. (c) peritumoral fibrotic tissue (mid part of the photomicrograph) is typically Gal3ST1 negative, while tumor (upper right corner) and peritumoral atrophic renal tubuli (lower left part) show strong or weak to moderate expression of Gal3ST1, respectively. (d) other patterns of Gal3ST1 distribution and intensity in RCC (IG—intensity grade). (a–c) HE staining – upper row, Gal3ST1 immunohistochemistry—lower row; (a,d): 200×, (b,d): 100 × magnification.