Table 4 Changes in expression (fold change - FC) and false discovery rate (FDR) for transcripts related to retinal ganglion cells, retinal cells and glial cells at 1- and 5-weeks post injury.
From: Axonopathy precedes cell death in ocular damage mediated by blast exposure
Time-point | 1 week | 5 weeks | ||||
|---|---|---|---|---|---|---|
Gene name | Name | Expressed in | logFC | FDR | logFC | FDR |
Rho | Rhodopsin | Rods | − 2.35E−02 | 9.20E−01 | 3.84E−02 | 6.22E−01 |
Nrl | Neural retina leucine zipper gene | Rods | − 1.93E−02 | 9.06E−01 | 6.17E−02 | 3.43E−01 |
Arr3 | Arrestin 3, retinal | Cones | − 4.29E−01 | 6.08E−03 | 2.14E−03 | 9.94E−01 |
Opn1mw | Opsin 1 medium-wave-sensitive | Cones | − 1.28E−01 | 3.74E−01 | 2.92E−02 | 8.87E−01 |
Vsx2 | Visual system homeobox 2 | Bipolar cells | 3.64E−03 | 9.88E−01 | 2.15E−02 | 9.19E−01 |
Otx2 | Orthodenticle homeobox 2 | Bipolar cells | 3.68E−02 | 7.20E−01 | 4.75E−02 | 5.10E−01 |
Chat | Choline acetyltransferase | Amacrine cells | − 1.31E−01 | 3.91E−01 | − 2.46E−02 | 9.47E−01 |
Th | Tyrosine hydroxylase | Amacrine cells | − 1.81E−01 | 5.84E−01 | 2.79E−02 | 9.61E−01 |
Lhx1 | LIM homeobox protein 1 | Horizontal cells | − 1.06E−01 | 8.07E−01 | 1.86E−01 | 5.50E−01 |
Prox1 | Prospero homeobox 1 | Horizontal cells | 2.53E−02 | 9.36E−01 | 1.15E−01 | 7.56E−02 |
Vim | Vimentin | Muller glia | 8.32E−01 | 3.13E−03 | 5.37E−02 | 6.08E−01 |
Gfap | Glial fibrillary acidic protein | Muller glia/astrocytes | 3.19E+00 | 2.40E−03 | 4.05E−01 | 2.32E−01 |
Tmem119 | Transmembrane protein 119 | Microglia | 1.23E+00 | 1.19E−03 | − 2.88E−02 | 9.74E−01 |
Cx3cr1 | Chemokine (C-X3-C motif) receptor 1 | Microglia | 1.31E+00 | 3.51E−04 | 1.97E−01 | 5.31E−01 |
Aif1 | Allograft inflammatory factor 1 | Microglia | 1.72E+00 | 3.59E−04 | ||
C1qa | Complement component 1, q subcomponent, alpha polypeptide | Microglia | 1.95E+00 | 1.20E−03 | 3.77E−01 | 1.09E−01 |
Nefm | Neurofilament, medium | RGCs | − 7.11E−01 | 3.64E−04 | − 8.41E−01 | 1.54E−08 |
Thy1 | Thymus cell antigen 1, theta | RGCs | − 4.94E−01 | 1.31E−03 | − 5.14E−01 | 1.39E−07 |
Sncg | Synuclein, gamma | RGCs | − 7.70E−01 | 9.40E−04 | − 7.66E−01 | 1.39E−07 |
Nefl | Neurofilament, light | RGCs | − 7.86E−01 | 1.01E−03 | − 7.48E−01 | 1.72E−07 |
Nefh | Neurofilament, heavy | RGCs | − 9.31E−01 | 4.43E−04 | − 6.92E−01 | 2.26E−07 |
Rbpms | RNA binding protein with multiple splicing | RGCs | − 5.06E−01 | 5.84E−03 | − 6.48E−01 | 2.53E−07 |
Tubb3 | Tubulin, beta 3 class III | RGCs | − 4.55E−01 | 2.62E−04 | − 5.33E−01 | 3.65E−07 |
Pvalb | Parvalbumin | RGCs | − 1.20E+00 | 1.18E−03 | − 9.79E−01 | 1.62E−06 |
Pou4f1 | POU domain, class 4, transcription factor 1 | RGCs | − 4.98E−01 | 5.63E−04 | − 6.93E−01 | 3.52E−05 |
Pou4f2 | POU domain, class 4, transcription factor 2 | RGCs | − 5.17E−01 | 4.41E−02 | − 5.55E−01 | 6.10E−04 |
Pou4f3 | POU domain, class 4, transcription factor 3 | RGCs | − 6.08E−01 | 5.70E−02 | − 7.95E−01 | 2.02E−03 |
Rbfox3 | RNA binding protein, fox-1 homolog (C. elegans) 3 | RGCs | − 3.81E−01 | 4.20E−03 | − 3.48E−01 | 1.93E−03 |
Chrna6 | Cholinergic receptor, nicotinic, Alpha polypeptide 6 | RGCs | − 6.14E−01 | 5.61E−04 | − 4.41E−01 | 4.12E−06 |
Opn4 | Opsin 4 (melanopsin) | ipRGCs | − 3.70E−01 | 2.35E−02 | − 1.54E−01 | 6.21E−01 |
Jam2 | Junction adhesion molecule 2 | J-RGCs | − 3.92E−03 | 9.83E−01 | − 3.29E−02 | 8.06E−01 |
Spp1 | Osteopontin | alpha RGCs | 5.11E−01 | 2.00E−02 | − 6.05E−01 | 2.19E−04 |
Kcng4 | Potassium voltage-gated channel, subfamily G, member 4 | alpha RGCs | − 8.92E−02 | 5.28E−01 | 1.24E−02 | 9.60E−01 |
Cartpt | Potassium voltage-gated channel, subfamily G, member 4 | ooDSGC | − 3.16E−01 | 1.58E−01 | − 6.04E−02 | 7.74E−01 |
