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Figure 1

From: Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

Figure 1

Post-simulated spaceflight conditions display distinct transcriptomics. Mice spleens collected 7-days following hindlimb unloading (HLU, green), low-dose irradiation (LDR, 0.04 Gy total dose, yellow), and combined HLU and LDR (simSpace, blue) for 21-days, compared to controls (orange). Principal component analysis (PCA) plot indicated for each condition (A). Venn diagrams for downregulated (B) and upregulated (C) genes. (D) Calculated coefficient of gene expression variation (CV) per gene plotted against the Log2 of the mean normalized count for that gene (+ 1) in each group. A one-way ANOVA with post hoc pairwise t tests (using step-down method, Sidak for adjusting p values) was performed in (D). Data represents n = 3–6 per group.

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