Figure 5
Distinct hematological gene expressions in spleens and red blood cell distributions in circulating blood post-simulated spaceflight. Whole blood was collected and red blood cell, RBC, × 106 per mm3 (A), hemoglobin, HGB, g/dL (B), mean corpuscular hemoglobin, MCH, pg (C), mean corpuscular hemoglobin concentration, MCHC, g/dL (D), hematocrit, HCT, % (E), RBC distribution width, RDW, % (F), and mean corpuscular volume, MCV, fL (G). (H) Human blood disease/disorders as per Malacards Human Disease Databases (cite) displays human orthologs to mouse DEG. (I) Network Analyst Global EnrichNetwork tool mapped blood disease/disorder genes that shared common pathways. Cell numbers were normalized to controls. Data represents ± SEM, n = 6 per group. An unpaired, parametric t test with Welch’s correction was performed for (A–G), *p < 0.05.
