Figure 3 | Scientific Reports

Figure 3

From: A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants

Figure 3

Kaplan–Meier estimated by rs2075786 genotypes in MSH2 pathogenic variant carriers. The graph shows the effect the genotypes has on age of diagnosis of Lynch Syndrome (LS) cancer in LS patients. A significant difference in the age of diagnosis of LS cancer can be seen between the three genotypes (Log-rank p = 0.0011, Wilcoxon p = 0.0006 and Tarone-Ware p = 0.0007). LS patients over the age of 50 years and carriers of the A allele (GA and AA genotype) will develop LS cancer earlier than LS patients carrying the GG genotype will.

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