Table 1 Demographic data. (A) Displays demographics for the combined LS cohort (rs2075786 and rs2736108 + rs7705526), while (B) Displays demographics for the four countries separately.
A | Samples n | Average age* years | Gender Male (%) / female (%) | Gene MLH1 (%) / MSH2 (%) / MSH6 (%) |
|---|---|---|---|---|
rs2075786 (n = 1895) | ||||
LS cancer | 830 | 45 (16–81) | 351 (42)/479 (58) | 363 (44) / 342 (41)/124 (15)* |
CRC | 632 | 44 (16–79) | 316 (50)/316 (50) | 315 (50) / 250 (40)/66 (10) |
Cancer-free | 1065 | 42 (11–89) | 451 (42)/614 (58) | 472 (44) / 363 (34)/230 (22) |
Total | 1895 | |||
rs2736108 and rs7705526 (n = 1241) | ||||
LS cancer | 633 | 45 (18–84) | 266 (42)/367 (58) | 292 (46) / 260 (41) / 81 (13) |
503 | 44 (18–79) | 241 (48)/262 (52) | 259 (51) / 199 (40) / 45 (9) | |
Cancer-free | 608 | 40 (12–81) | 246 (40)/362 (60) | 303 (50) / 205 (34) / 100 (16) |
Total | 1241 | |||
B | Sample cohort demographics by country | |||
|---|---|---|---|---|
Samples n | Average age* Years (range) | Gender Male (%) / female (%) | Gene MLH1 (%)/MSH2 (%)/MSH6 (%) | |
LS cancer AU | 298 | 45 (19–81) | 173 (58)/125 (42) | 106 (36)/136 (46)/56 (18) |
LS cancer PL | 189 | 45 (18–71) | 121 (64)/68 (36) | 101 (54)/74 (39)/14 (7) |
LS cancer ES | 146 | 44 (21–79) | 73 (50)/72 (50) | 85 (58)/50 (34)/11 (8) |
LS cancer NL | 197 | 45 (16–78) | 112 (57)/85 (43) | 71 (36)/82 (42)/43 (22) |
Total | 803 | |||
CRC AU | 218 | 44 (19–75) | 113 (52)/105 (48) | 92 (42)/99 (45)/27 (13) |
CRC PL | 150 | 44 (18–69) | 86 (58)/64 (42) | 85 (57)/55 (37)/10 (6) |
CRC ES | 135 | 44 (21–79) | 63 (47)/71 (53) | 82 (61)/45 (33)/8 (6) |
CRC NL | 129 | 44 (16–72) | 54 (42)/75 (58) | 56 (43)/51 (40)/21 (17) |
Total | 632 | |||
Cancer-free AU | 321 | 40 (11–81) | 196 (61)/124 (39) | 129 (40)/112 (35)/80 (25) |
Cancer-free PL | 193 | 39 (13–73) | 116 (60)/77 (40) | 114 (59)/68 (35)/11 (6) |
Cancer-free ES | 94 | 41 (12–82) | 50 (53)/44 (47) | 60 (64)/25 (26)/9 (10) |
Cancer-free NL | 457 | 45 (20–89) | 252 (55)/205 (45) | 169 (37)/158 (35)/130 (28) |
Total | 1065 | |||
