Figure 8
From: Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice
Expression of FGFR protein and MAPK/ERK signaling in skeletal muscle from WT and Fgf2KO mice. Young (5 m) and old (20 m) WT and Fgf2KO mouse triceps muscles were isolated and total protein extracted for western blotting. (a) phosphoFGFR1 Western blot and (b) quantification. (c) phosphoFGFR3 Western blot and (d) quantification. (e) phosphoFGFR4 Western blot and (f) quantification. (g) phosphoERK and total ERK Western blot and (h) quantification. (a,b) phosphoFGFR1; (c,d) phosphoFGFR3 were significantly increased, while (e,f) phosphoFGFR4 was significantly decreased in old muscle of both genotypes. (g,h) phosphoERK1/2 was significantly increased in 20 m old as well 5 m and 20 m Fgf2KO compared with 5 m WT. n = 3 mice/group. *Compared to corresponding WT p < 0.05, #compared to corresponding 5 m p < 0.05.
