Figure 2 | Scientific Reports

Figure 2

From: Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations

Figure 2

RNAseq of LCM isolated epithelia from 8 non-SS and 8 SS patients. (a) PCA of total gene expression data reveals segregation between non-SS (Group A) and SS (Group B) samples and similarities between non-SS and SS (Group AB), identifying a new sub-group with mixed clinical features but the same transcriptional profile. Groups were defined as: Group A (non-SS, n = 3), Group AB (mixed non-SS/SS, n = 10), and Group B (SS, n = 3). (b) Sample-sample distance heat map further clusters the sample set. (c) Comparison of outputs of the number differentially expressed (DE) genes at different filtered FDR cut-off levels. When the biopsies were analyzed for DE genes by RNAseq cluster, a greater number of DE genes were observed.

Back to article page