Figure 4 | Scientific Reports

Figure 4

From: Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway

Figure 4

Heptelidic acid showed the anti-tumor effect in vitro and in vivo. The SRB assay showed that heptelidic acid exerted a growth-suppression effect against SUIT-2 (A), MIA-PaCa-II (B) and PANC-1 (C) cells in a concentration-dependent manner. SUIT-2 cells were transplanted into nude mice, and 10 μg of heptelidic acid was injected daily to the tumor. The growth of the tumor was significantly inhibited by treatment with heptelidic acid (D). Heptelidic acid or 5-FU was injected into the small intestine of mice and incubated in culture media for 2, 6 and 18 h. The SRB assay showed the anti-tumor effect of the media collected from outside the intestine enclosed with heptelidic acid or 5-FU (E). The error bars show the standard deviation (S.D.) (A,B,C,E; n = 3, D; n = 5).

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