Figure 7
From: ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis
TNF RI shedding in CCl4 intoxication. (a) Higher shedding of TNF RI into serum was observed 4 weeks after CCl4 treatment in all studied groups as determined by ELISA. ADAM17ΔAlb mice had lower levels of soluble TNF RI (sTNF RI) than control littermates, while in ADAM10ΔAlb mice sTNF RI levels were elevated (n indicated above the bars, mean ± SEM, *p < 0.05, **p < 0.01). (b) Expression of TnfrI transcript in livers after CCL4 treatment was determined by q-PCR. Values were normalized to Gapdh and Hprt. (n = 5 per group, mean ± SEM).
