Figure 2 | Scientific Reports

Figure 2

From: Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP

Figure 2

hPDGFRβ is expressed in the basement membrane of vessels in the skin, and around large blood vessels in the liver. Formalin fixed paraffin embedded sections of normal human skin and liver were stained for CD31 (blue) and PDGFRβ (brown). (A) Staining for the endothelial marker CD31 could be seen in the lumen of all skin vasculature irrespective of the size. PDGFRβ was detected surrounding these vascular structures but was not associated with the luminal side of the vessel. Boxed area enlarged in A′. (B) CD31 staining was observed in liver sinusoidal endothelial cells (LSEC) all throughout the liver and also in the lumen of major blood vessels. Very low levels of PDGFRβ staining was detected surrounding large blood vessels but was not associated with the luminal surface of the vessel. No PDGFRβ staining was seen around LSECs. Boxed area enlarged in B′. Scale bars are 100 µm.

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