Figure 6
From: Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation
(A) Spatial response image recorded from 5 ms optical pulses from a RWM-positioned optical fibre in an AAV-injected C57BL/6 mouse with 55% ChR2-H134R-EYFP transduced cells in the apical turn but no basal turn expression (expression pattern shown in Fig. 3). The dorsal best electrode in this response image is suggestive of activation of apical turn neurons (B) Response image from the same mouse generated from an apically-positioned optical fibre (5 ms pulse). (C) No multiunit inferior colliculus activity was recorded in a mouse that had no detectable expression of ChR2-H134R-EYFP in any cochlear turn (image from 10 ms optical pulse). Response images were generated as per Fig. 4. The dotted lines compare the width of activation at an equivalent level above threshold (d’ = 1 above threshold).
