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Figure 1

From: C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary hypertension by regulating secretion of endothelin-1 and nitric oxide mediated by AMPK in rats

Figure 1

Hypoxia induced cardiopulmonary remodeling and reduction of serum CTRP9 content in rats. (A–D) Quantitative data of cardiopulmonary hemodynamics, including right ventricular systolic pressure (RVSP, A), mean carotid artery pressure (mCAP, B), and right ventricular hypertrophy index (C, D), are presented. € Paraffin-embedded sections of rat lungs were assessed for pulmonary arterial remodeling by staining (hematoxylin & eosin; × 200 magnification). Scale bar = 20 μm. (F, G) Blinded quantitative analyses of MT% and MA% of peripheral pulmonary arteries (30 vessels/3 sections from one animal, 30–100 μm in diameter) were done using Image-Pro Plus. (H) CTRP9 concentrations in the serum of rats suffering hypoxia or not (n = 6). Data are the mean ± SEM. ※P < 0.05, ※※P < 0.01 vs. normoxia group. N normoxia for 4 weeks, H2 hypoxia for 2 weeks, H4 hypoxia for 4 weeks.

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