Table 2 Association between SU as a continuous variable and subsequent CVD and MACE events by sex, unadjusted and with minimal adjustment for age and mean DCCT/EDIC HbA1c.

From: Serum urate and cardiovascular events in the DCCT/EDIC study

 

Men (n = 540)

Women (n = 433)

No. of Participants (%)a

HR (95% CI)b

p-value unadjusted

HR 95% CI)b

p-value adjusted

No. of Participants (%)a

HR

(95% CI)b

p-value

unadjusted

HR (95% CI)b

p-value adjusted

Any cardiovascular disease event

61 (11)

1.18 (0.92–1.50)

0.1920

1.15 (0.90–1.46)

0.2717

49 (11)

1.22 (0.93–1.60)

0.1544

1.17 (0.88–1.56)

0.2833

1. Non-fatal acute myocardial infarction

16 (3)

  

15 (3)

  

2. Non-fatal cerebrovascular event

7 (1)

  

7 (2)

  

3. Death from cardiovascular disease

6 (1)

  

5 (1)

  

4. Silent myocardial infarction

13 (2)

  

14 (3)

  

5. Confirmed angina

6 (1)

  

12 (3)

  

6. Revascularization

37 (7)

  

22 (5)

  

7. Congestive heart failure

3 (1)

  

1 (< 1)

  

Non-fatal MI or stroke or death from cardiovascular disease (MACE)

29 (5)

1.13 (0.79–1.61)

0.5083

1.10 (0.77–1.58)

0.5944

24 (6)

1.52 (1.07–2.16)

0.0211

1.47 (1.01–2.14)

0.0466

1. Non-fatal acute myocardial infarction

16 (3)

  

15 (3)

  

2. Non-fatal cerebrovascular event

7 (1)

  

7 (2)

  

3. Death from cardiovascular disease

6 (1)

  

5 (1)

  
  1. aNumber of participants with each type of event, regardless of whether or not it is the initial event for that subject (including recurrent events).
  2. bCox proportional hazard regression models minimally adjusted for age and mean DCCT/EDIC HbA1c as fixed covariates at the time of the SU measurement.