Table 2 Experimental studies investigating the protective role of autophagy during liver regeneration.
Year | Author | Experimental model | Surgical strategy | Pharmacological intervention | Autophagy | Regeneration | ||
|---|---|---|---|---|---|---|---|---|
Parameter | Observation time | Parameter | Observation time | |||||
2014 | Toshima et al.35 | Wild-type Atg5 Mice | 70%PHx | / | LC3-II++, P62+ | POD1 | BrdU+++, Cyclin D+++ | POD1 |
L-Atg5KO micea | 70%PHx | / | LC3-II−−−, P62+++ | POD1 | BrdU+, Cyclin D− | POD1 | ||
Hepatocytes | / | HGFb | LC3-II+++ | / | Cyclin D+++ | / | ||
2015 | Lin et al.34 | C57BL/6 Mice | 70%PHx | / | LC3-II++, P62+ | POD1 | Ki67++, PCNA++ | POD2 |
Amiodarone | LC3-II+++, P62− | POD1 | Ki67+++, PCNA+++ | POD2 | ||||
Chloroquine | LC3-II+++, P62+++ | POD1 | Ki67+, PCNA− | POD2 | ||||
2016 | Shi et al.32 | BALB/c mice | / | CCl4 | LC3-II+++, P62+++ | POD2 | PCNA−−−, CyclinD−−− | POD2 |
CCl4 + ALR | LC3-II+++, P62−−− | POD2 | PCNA+++, Cyclin D+++ | POD2 | ||||
CCl4 + 3-MAc | / | / | PCNA−−−, CyclinD−−− | POD2 | ||||
2018 | Lu et al.36 | C57BL/6 Mice | 70%PHx | miR-1907 | LC3-II+++, P62−−− | POD2 | BrdU+++, PCNA+++ | POD2 |
2019 | Jia et al.37 | SD rats | 70%PVL | / | LC3-II+++ | POD1 | Cyclin D+++ | POD1 |
2019 | Matsumoto et al.39 | C57BL/KsJ m + /m + mice(control) | 70%PHx | / | LC3-II+++, P62- | POD1 | PCNA+++, Cyclin D+++ | POD2 |
C57BL/KsJ db/db miced | 70%PHx | / | LC3-II+++, P62+++ | POD1 | PCNA+, Cyclin D− | POD2 | ||
