Table 3 Association between %BF and protein levels stratified by BMI categories.

Protein	Normal weight (18.5 to < 25 kg/m²)			Overweight/ obesity (≥ 25 kg/m²)			p-value interact	p-value interact*
Protein	Coef	95% CI	p-value	Coef	95% CI	p-value	p-value interact	p-value interact*
CCL3	0.34	0.23 to 0.46	< 0.001	0.60	0.43 to 0.77	< 0.001	0.159	0.041
CCL20	0.09	− 0.03 to 0.20	0.232	0.37	0.19 to 0.55	< 0.001	0.120	0.023
CDCP1	0.27	0.16 to 0.38	< 0.001	0.88	0.71 to 1.05	< 0.001	0.005	< 0.001
DNER	− 0.19	− 0.31 to − 0.08	0.007	− 0.30	− 0.47 to − 0.12	0.002	0.161	0.044
FGF21	0.30	0.19 to 0.42	< 0.001	0.74	0.58 to 0.91	< 0.001	0.111	0.019
FGF23	0.07	− 0.05 to 0.19	0.343	0.56	0.39 to 0.72	< 0.001	0.030	0.003
HGF	0.12	0.01 to 0.23	0.082	0.72	0.57 to 0.87	< 0.001	< 0.001	< 0.001
IL6	0.50	0.39 to 0.61	< 0.001	0.86	0.72 to 1.00	< 0.001	< 0.001	< 0.001
IL18	0.14	0.02 to 0.26	0.057	0.46	0.30 to 0.63	< 0.001	0.157	0.035
LAPTGFbeta1	− 0.03	− 0.14 to 0.09	0.733	0.33	0.15 to 0.50	0.001	0.032	0.004
MCP1	− 0.10	− 0.21 to 0.01	0.153	0.36	0.20 to 0.53	< 0.001	0.030	0.003
MCP4	− 0.08	− 0.20 to 0.04	0.255	0.27	0.11 to 0.44	0.003	0.005	< 0.001
OSM	0.02	− 0.10 to 0.13	0.843	0.35	0.18 to 0.52	< 0.001	0.111	0.018
TNFSF14	0.15	0.04 to 0.26	0.034	0.38	0.21 to 0.54	< 0.001	0.121	0.025

Stratified analyses in BMI categories from linear regression of transformed protein levels adjusted for sex, smoking, e-cigarette use, snuff use, and age at follow-up.
The table includes all proteins with unadjusted p-value for the interaction term %BF#BMI_category of < 0.05.
p-values at 0.05 FDR.
*p-value for the interaction term without FDR correction.

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