Figure 1

(A) Segmental linear regression of detectable C-peptide levels versus Type 1 diabetes duration. Overall r = 0.45, slope before threshold p = 0.0005, slope after threshold p = 0.66; diabetes duration threshold 8.8 (95% CI 5.7, 11.9) years (p < 0.0001). (B) Comparison of proportion of detectable C-peptide in participants with diabetes stratified by age of diabetes diagnosis and duration. Significant positive trend in percentage of detectable C-peptide with diabetes duration in diabetes diagnosed below 18 y.o. (p = 0.01) and borderline negative trend in diabetes diagnosed ≥ 18 y.o. (p = 0.07).