Table 6 The comparison of CAD associated risk factors between different genotypes of rs2483205 and rs562556 polymorphisms.

From: Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors

Parameters

rs2483205

rs562556

CC genotype (n = 1010)

CT genotype (n = 858)

TT genotype (n = 163)

t /\(\chi^{2}\)

p value

A allele (n = 1814)

G allele (n = 188)

t /\(\chi^{2}\)

p value

LDL-C,mmol/L

2.70 ± 0.80

2.65 ± 0.88

2.61 ± 0.81

0.83

0.438

2.71 ± 0.99

2.41 ± 0.97

4.28

0.048*

TG,mmol/L

2.05 ± 2.77

2.06 ± 2.94

1.83 ± 1.33

0.45

0.636

1.61 ± 1.27

1.36 ± 0.80

4.25

0.400

TC,mmol/L

4.34 ± 1.77

4.62 ± 2.62

3.91 ± 1.20

3.34

0.036*

4.29 ± 0.94

4.17 ± 0.88

1.08

0.300

HDL,mmol/L

1.18 ± 0.67

1.15 ± 0.72

1.13 ± 0.42

0.49

0.615

1.16 ± 0.66

1.10 ± 0.41

0.14

0.230

Glucose,mmol/L

5.78 ± 2.27

5.63 ± 2.14

5.43 ± 2.03

2.15

0.116

5.74 ± 2.24

5.22 ± 1.75

8.86

0.003*

Diabetes, n (%)

65 (6.43)

62 (7.23)

9 (5.52)

0.86

0.650

128 (6.95)

8 (4.19)

2.12

0.171

BMI,kg/m2

25.76 ± 3.78

26.09 ± 3.83

26.34 ± 3.59

2.72

0.066

25.88 ± 3.77

26.54 ± 3.92

5.19

0.023*

Obesity, n (%)

242 (23.94)

250 (29.14)

46(28.22)

6.73

0.035*

477 (25.91)

61 (32.45)

4.83

0.089

  1. LDL-C low density lipoprotein-cholesterol, TG triglyceride, TC total cholesterol, HDL high density lipoprotein-cholesterol, BMI body mass index.
  2. *p-values < 0.05.
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