Table 2 Deflection of biochemical indices in HCC patients (n = 87).

From: The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment

 

Tandem size

P-value

Doxorubicin loading

P-value

75 μm (n = 26)

100 μm (n = 61)

Half-loaded (n = 15)

Full-loaded (n = 72)

Before

After

Before

After

Before

After

Before

After

AST (U/L)

Mean ± SD

61.4 ± 51.4

78.5 ± 68.2

56.4 ± 32.5

107.6 ± 135.6

 

42.9 ± 20.6

50.2 ± 19.2

61.0 ± 41.1

109.0 ± 129.3

 

Difference

17.1 ± 36.4

51.2 ± 133.2

0.547

7.3 ± 27.4

48.0 ± 123.8

0.120

ALT (U/L)

Mean ± SD

50.6 ± 50.4

67.0 ± 61.8

41.2 ± 25.8

72.1 ± 91.4

 

38.3 ± 21.3

45.8 ± 31.6

45.2 ± 37.2

75.8 ± 89.7

 

Difference

16.4 ± 29.5

30.9 ± 82.8

0.915

7.5 ± 24.9

30.6 ± 77.0

0.146

T-bil (mg/dL)

Mean ± SD

0.8 ± 0.3

1.1 ± 0.5

0.9 ± 0.6

1.3 ± 1.1

 

1.0 ± 0.5

1.2 ± 0.7

0.9 ± 0.6

1.3 ± 1.0

 

Difference

0.3 ± 0.4

0.4 ± 0.6

0.788

0.2 ± 0.4

0.4 ± 0.6

0.353

Albumin (g/dL)

Mean ± SD

3.9 ± 0.5

3.8 ± 0.6

3.8 ± 0.6

3.8 ± 0.7

 

3.6 ± 0.4

3.5 ± 0.5

3.9 ± 0.6

3.9 ± 0.7

 

Difference

− 0.1 ± 0.3

− 0.04 ± 0.6

0.187

− 0.1 ± 0.3

− 0.1 ± 0.5

0.566

PLT (103/μl)

Mean ± SD

121.5 ± 67.4

122.4 ± 65.5

148.6 ± 76.0

150.6 ± 75.7

 

132.6 ± 51.0

139.4 ± 70.9

142.2 ± 78.3

142.8 ± 74.6

 

Difference

0.9 ± 51.4

2.0 ± 60.2

0.784

6.8 ± 57.0

0.6 ± 57.9

0.567

CRE (mg/dL)

Mean ± SD

1.4 ± 1.9

1.3 ± 1.7

1.0 ± 0.6

1.0 ± 0.5

 

1.3 ± 0.6

1.3 ± 0.6

1.1 ± 1.2

1.0 ± 1.1

 

Difference

− 0.04 ± 0.2

− 0.03 ± 0.2

0.897

− 0.04 ± 0.3

− 0.04 ± 0.2

0.629

  1. Mann–Whitney test used to compare changes of values from baseline between different TANDEM size or different doxorubicin-loading dose.
  2. AST aspartate aminotransferase, ALT alanine aminotransferase, T-bil Total bilirubin, PLT platelet, CRE creatinine.
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