Table 4 Regression coefficients (95% CI) of HbA1c and covariates associated with HDL-c and Non HDL-c by glycemic categories and gender in the Health Survey for England.

From: Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations

HS-England

                                                            Male

                                                         Female

HDL-c

Overall

NGH

IGH

Diabetes

Overall

NGH

IGH

Diabetes

HbA1c

 − 0.003 (− 0.006, − 0.001)0.008

0.005 (− 0.004, 0.013)0.2

 − 0.0003 (− 0.021, 0.021)0.9

 − 0.001 (− 0.005, 0.003)0.5

 − 0.003 (− 0.006, − 0.0004)0.02

 − 0.006 (− 0.014, 0.003)0.1

 − 0.021 (− 0.04, − 0.003)0.02

0.002 (− 0.002, 0.006)0.2

Age

0.004 (0.003, 0.006)<0.001

0.005 (0.003, 0.007)<0.001

0.002 (− 0.002, 0.007)0.3

 − 0.001 (− 0.006, 0.004)0.7

0.009 (0.008, 0.010)<0.001

0.010 (0.009, 0.012)<0.001

0.008 (0.005, 0.011)<0.001

0.0002 (− 0.008, 0.008)0.9

Waist circumference

 − 0.010 (− 0.012, − 0.008)<0.001

 − 0.011 (− 0.013, − 0.008)<0.001

 − 0.01 (− 0.013, − 0.006)<0.001

 − 0.007 (− 0.012, − 0.002)0.006

 − 0.014 (− 0.016, − 0.013)<0,001

 − 0.014 (− 0.016, − 0.013)<0.001

 − 0.013 (− 0.016, − 0.011)<0.001

 − 0.006 (− 0.015, 0.003)0.1

Non HDL-c

Overall

NGR

IGH

Diabetes

Overall

NGR

IGH

Diabetes

HbA1c

0.004 (− 0.008, 0.015)0.5

0.033 (0.009,0.057)0.008

 − 0.001 (− 0.059,0.056)0.9

0.016 (− 0.003, 0.034)0.1

0.010 (0.002, 0.02)0.01

0.050 (0.030, 0.070)<0.001

 − 0.015 (− 0.061, 0.032)0.5

 − 0.005 (− 0.018, 0.008)0.4

Age

0.011 (0.007, 0.015)<0.001

0.012 (0.006, 0.017)<0.001

 − 0.007 (− 0.019,0.006)0.2

 − 0.013 (− 0.031, 0.005)0.1

0.027 (0.024, 0.031)<0.001

0.024 (0.019, 0.028)<0.001

0.020 (0.010, 0.030)<0.001

0.006 (− 0.032,0.045)0.7

Waist circumference

0.030 (0.026, 0.038)<0.001

0.036 (0.030, 0.042)<0.001

0.022 (0.010,0.033)<0.001

0.015 (0.001, 0.030)0.04

0.018 (0.014, 0.022)<0.001

0.018 (0.013, 0.022)<0.001

0.017 (0.010, 0.020)<0.001

0.008 (− 0.012,0.028)0.4

  1. HbA1c Hemoglobin A1c, BMI body mass index, HDL-c high density lipoprotein cholesterol, NGH normal glucose homeostasis (HbA1c < 5.7%), IGH impaired glucose homeostasis (HbA1c 39 to < 42 mmol/mol), diabetes; HbA1c ≥ 48 mmol/mol and/or currently taking a glucose lowering agent and/or self-reported previous diabetes diagnosis by doctor. In addition to those shown, predictor variables included in each multivariable model also included lipid lowering agent use, smoking, alcohol status, total energy intake and physical activity status.
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