Table 3 Gene’s products and blood or cell lineage using the Human Protein Atlas database were explored https://www.proteinatlas.org/.
Genes | Secretome annotation | RNA blood cell lineage specificity | RNA blood cell lineage distribution | RNA blood cell type specificity | RNA blood cell type distribution |
|---|---|---|---|---|---|
SFN | Secreted in other tissues | Lineage enriched (granulocytes) | Detected in single | Cell type enriched (basophil) | Detected in single |
SERPINE1 | Secreted to blood | Lineage enriched (NK-cells) | Detected in single | Cell type enriched (NK-cell) | Detected in single |
ANLN | Intracellular | Low lineage specificity | Detected in single | Cell type enhanced (T-reg) | Detected in single |
KRT8 | Intracellular | Group enriched (dendritic cells, granulocytes, NK-cells) | Detected in many | Cell type enhanced (plasmacytoid DC) | Detected in some |
MKI67 | Intracellular | Group enriched (T-cells, NK-cells) | Detected in many | Cell type enhanced (naive CD4 T-cell, T-reg) | Detected in some |
GPRC5A | Intracellular, Membrane | Lineage enriched (granulocytes) | Detected in single | Cell type enhanced (basophil) | Detected in some |
TOP2A | Intracellular | Low lineage specificity | Detected in many | Cell type enhanced (T-reg) | Detected in some |
ABCA1 | Intracellular, Membrane | Lineage enriched (granulocytes) | Detected in many | Group enriched (eosinophil, neutrophil) | Detected in many |
RRM2 | Intracellular, Membrane | Lineage enriched (T-cells) | Detected in many | Cell type enhanced (T-reg) | Detected in many |
NEK2 | Intracellular | Low lineage specificity | Detected in many | Low cell type specificity | Detected in many |
