Figure 1
From: Maximizing the potential of aggressive mouse tumor models in preclinical drug testing
Fitness-based preclinical testing approach employing tumor model of the most aggressive tumor spectrum. (a) Widely used preclinical mouse models are not the most accurate and lack the aggressive tumor spectrum found within a single tumor type. Our fitness-based approach enabled us to employ the most aggressive tumor model for preclinical testing despite the short murine laboratory life-span. (b) Schematic illustrating conventional approach of administering drug for the same duration in each mice of the treatment cohort, in comparison to our current fitness-adapted approach of clinically staging the mice, matching their suitability to continue on ispinesib treatment regimen. (c) Eight staging parameters for general health fitness, and challenge tests to elicit neurological signs.
