Figure 3
From: Pirfenidone modifies hepatic miRNAs expression in a model of MAFLD/NASH
Immunoreactivity against CD68 and GFAP. (A) In animals fed with high fat-high carbohydrate diet an increase in CD68 immunoreactivity was observed. Animals treated with PFD showed a significant reduction in CD68 positive area (****p < 0.0001). (B) Quantification of GFAP positive area in liver tissue showed an increased in PFD animals (****p < 0.0001). Photographs at ×20 magnification. HFD: high fat and high carbohydrate diet and PFD: high fat and high carbohydrate diet + prolonged-release pirfenidone. Data are expressed as the media of the group ± SEM.
