Table 3 AUROC, NRI, and IDI by subgroup.

From: Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit

Variable

11-gene score

SAPS 3

APACHE II

24 h emergency department cutoff

AUROC (95% CI)

0.68 (0.52–0.84)

0.69 (0.54–0.83)

0.72 (0.58–0.85)

NRI (95% CI)

 

0.45* (0.05–0.84)

0.57** (0.22–0.93)

IDI (95% CI)

 

0.07* (0.01–0.14)

0.08* (0.01–0.15)

Shock patients

AUROC (95% CI)

0.77 (0.6–0.95)

0.64 (0.43–0.85)

.76 (0.59–0.93)

NRI (95% CI)

 

0.64* (0.08–1.2)

0.5* (0.003–1)

IDI (95% CI)

 

0.2** (0.06–0.34)

0.23** (0.08–0.38)

Primary determinant of prognosis is ARDS or MODS

AUROC (95% CI)

0.98 (0.93–1)

0.86 (0.67–1)

0.96 (0.88–1)

NRI (95% CI)

 

0.93** (0.36–1.5)

0.44 (− 0.11 to 0.99)

IDI (95% CI)

 

0.76** (0.39–1.12)

0.46* (0–0.92)

  1. Performance as measured by AUROC in predicting 60-day mortality of the 11-gene score, SAPS3, and APACHE II are outlined above. Additionally, the categorical Net-Reclassification (NRI) Index and Integrated Discrimation Improvement (IDI) Index are shown for the comparison of SAPS3 and APACHE II alone vs in combination with the 11-gene score using logistic regression modeling. NRI and IDI values greater than 0 are suggestive of improved prognostic performance with the addition of the 11-gene score.
  2. *P < 0.05.
  3. **P < 0.01.
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