Table 1 Baseline characteristics of study populations.

From: Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations

Variables

All participants

Survivors

Deaths

Pa

DFTJ cohort

No

30,521

27,210

3311

 

Males

13,685 (44.8)

11,519 (42.3)

2166 (65.4)

< 0.001

Age (years)

62.2 (56.2–68.0)

62.0 (55.8–66.3)

70.0 (64.0–76.0)

< 0.001

BMI (kg/m2)

24.1 (22.0–26.4)

24.1 (22.1–26.3)

24.2 (21.9–26.6)

0.67

Smokers

9034 (29.6)

7493 (27.5)

1541 (46.5)

< 0.001

Alcohol drinkers

8730 (28.6)

7596 (27.9)

1134 (34.3)

< 0.001

Education

< 0.001

Below high school

18,192 (59.6)

15,842 (58.2)

2350 (71.0)

 

High school

8499 (27.9)

7912 (29.1)

587 (17.7)

 

College or above

3466 (11.4)

3140 (11.5)

326 (9.9)

 

Missing

364 (1.2)

316 (1.2)

48 (1.5)

 

Physically active

24,544 (80.4)

22,036 (81.0)

2508 (75.8)

< 0.001

Disease history

Hypertension

16,678 (54.6)

14,395 (52.9)

2283 (69.0)

< 0.001

Hyperlipidemia

16,122 (52.8)

14,348 (52.7)

1774 (53.6)

0.36

Diabetes

6090 (20.0)

5027 (18.5)

1063 (32.1)

< 0.001

CVD

5226 (17.1)

4170 (15.3)

1056 (31.9)

< 0.001

Cancer

834 (2.7)

636 (2.3)

198 (6.0)

< 0.001

Neutrophils (× 109/L)

3.29 (2.61–4.10)

3.23 (2.60–4.03)

3.60 (2.84–4.50)

< 0.001

Lymphocytes (× 109/L)

1.83 (1.47–2.27)

1.82 (1.47–2.26)

1.87 (1.46–2.35)

0.01

Platelets (× 109/L)

188 (155–225)

189 (157–226)

176 (142–216)

< 0.001

SII (× 109/L) c

332.71 (236.91–467.61)

331.70 (237.40–465.00)

343.10 (229.48–487.99)

0.21

NHANES 1999–2014

No

25,761

20,933

4828

–

Males

12,640 (47.1)

9932 (46.5)

2708 (51.1)

< 0.001

Age (years)

54.5 (46.5–65.4)

52.8 (45.7–62.4)

71.7 (59.8–79.3)

< 0.001

Race

Non-hispanic white

12,892 (75.0)

9956 (74.4)

2936 (78.8)

< 0.001

Non-Hispanic Black

5132 (9.8)

4265 (9.8)

867 (10.1)

 

Mexican American

4276 (5.6)

3575 (5.8)

701 (4.0)

 

Other

3461 (9.6)

3137 (10.0)

324 (7.1)

 

BMI (kg/m2)

28.0 (24.6–32.2)

28.1 (24.7–32.3)

27.4 (24.0–31.6)

< 0.001

Smokers

12,985 (50.2)

10,135 (48.6)

2850 (60.2)

< 0.001

Alcohol drinkers

16,283 (68.2)

13,452 (69.6)

2831 (59.3)

< 0.001

Education

< 0.001

Below high school

8041 (19.5)

5955 (17.2)

2086 (33.7)

 

High school

5937 (24.6)

4796 (24.1)

1141 (27.4)

 

College or above

11,737 (55.8)

10,160 (58.6)

1577 (38.5)

 

Missing

46 (0.1)

22 (0.1)

24 (0.4)

 

Physically active

6798 (31.5)

5949 (33.3)

849 (19.9)

< 0.001

Disease history

Hypertension

14,392 (49.8)

10,918 (46.6)

3474 (70.0)

< 0.001

Hyperlipidemia

15,929 (62.2)

12,972 (62.0)

2957 (63.3)

0.17

Diabetes

5636 (16.3)

4155 (14.5)

1481 (27.7)

< 0.001

CVD

4184 (13.1)

2499 (9.8)

1685 (34.2)

< 0.001

Cancer

3249 (13.1)

2209 (11.5)

1040 (23.0)

< 0.001

Neutrophils (× 109/L)

3.97 (3.10–5.04)

3.93 (3.06–4.97)

4.26 (3.34–5.41)

< 0.001

Lymphocytes (× 109/L)

1.89 (1.51–2.37)

1.91 (1.54–2.38)

1.74 (1.33–2.27)

0.19

Platelets (× 109/L)

246 (208–291)

247 (209–292)

241 (199–289)

0.01

SII (× 109/L)c

505.14 (366.96–705.63)

497.68 (363.66–690.55)

562.92 (392.70–824.09)

< 0.001

  1. Values were presented as n (%) for categorical variables and median (interquartile range) for continuous variables.
  2. DFTJ Dongfeng-Tongji cohort, NHANES National Health and Nutrition Examination Survey, BMI body mass index, CVD cardiovascular diseases, SII systemic immune-inflammation index.
  3. aP values were calculated by the Chi-square test or Mann–Whitney U test.
  4. bP values were calculated by Rao-Scott χ2 test for categorical variables, which is design adjusted version of Pearson χ2 test, and by variance estimation adjusting for sampling weights for continuous variables.
  5. cFor each subject, SII value = neutrophil count/lymphocyte count × platelet count.
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