Figure 2
From: Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Rgene: A score of drug repositionability based on sharedness of drug target genes between a disease pair. (A) Schema of drug repositioning where a drug in disease A is repositioned to disease B, with information of drug target genes. Drugs and their target genes are differently positioned across the three regions (disease A only, disease B only, and disease A and B). (B) Calculation of Rgene as a score of drug target gene sharedness between disease A and disease B. (C) Log distribution of Rgene of 6808 disease pairs. Rgene of 2466 disease pairs (36.2%) was less than 1. Note: disease pairs which had no repositioned drugs are included. (D) Inter-disease network by Rgene. A circular network consists of 33 diseases from the top 100 Rgene disease pairs were depicted. The number of disease pairs (connected lines) are different among the diseases. Multiple sclerosis (ID:13) and Crohn’s disease (ID:96) are paired to many other diseases.
