Table 1 Top 10 Rgene disease pairs (A. Neuromuscular diseases, D. Immune diseases, M. Digestive diseases).
From: Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Rank | Disease A | Disease B | Rgene | ||
|---|---|---|---|---|---|
ID | Name | ID | Name | ||
1 | 13 | Multiple sclerosis [A] | 96 | Crohn’s disease [M] | 107.78 |
2 | 13 | Multiple sclerosis [A] | 46 | Malignant rheumatoid arthritis [D] | 103.88 |
3 | 2 | Amyotrophic lateral sclerosis [A] | 13 | Multiple sclerosis [A] | 99.64 |
4 | 46 | Malignant rheumatoid arthritis [D] | 96 | Crohn’s disease [M] | 92.11 |
5 | 6 | Parkinson’s disease [A] | 13 | Multiple sclerosis [A] | 82.27 |
6 | 46 | Malignant rheumatoid arthritis [D] | 97 | Ulcerative colitis [M] | 75.84 |
7 | 96 | Crohn’s disease [M] | 97 | Ulcerative colitis [M] | 75.07 |
8 | 2 | Amyotrophic lateral sclerosis [A] | 96 | Crohn’s disease [M] | 72.50 |
9 | 2 | Amyotrophic lateral sclerosis [A] | 6 | Parkinson’s disease [A] | 69.91 |
10 | 13 | Multiple sclerosis [A] | 97 | Ulcerative colitis [M] | 66.94 |
