Figure 3 | Scientific Reports

Figure 3

From: Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia

Figure 3

Effect of Rg1 on the recovery of hematopoietic function, mediated by the alleviation of Bax translocation-induced mitochondrial apoptosis, in LSK cells obtained from mice on day 14. (A) The numbers of BFU-Es and CFU-Es in different AA groups was detected to assess the efficacy of medium-dose Rg1. (B) The number of LSK cells in the control, model AA, and Rg1 treatment groups. (C) Mitochondrial DNA copy number determined by using real-time PCR. (D) Mitochondrial structure was detected by electron microscopy on day 14. (E) Apoptosis levels in LSKs determined by using flow cytometry. (F) Ros levels in LSK cells obtained from mice. (G) Levels of mitochondrial apoptosis-related proteins in LSKs. (H) The Bax ratio of LSKs in mitochondria and total. (I) Bax immunohistochemistry in different groups. *P < 0.05 and **P < 0.01 compared with the model control group.

Back to article page