Table 3 Characteristics of individuals according to terciles of polygenic risk score.

From: Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents

 

Continuous data (mean ± SD)

PRS-T1 (− 2.60 to − 0.30)

PRS-T2 (− 0.30 to 0.41)

PRS-T3 (0.43 to 3.52)

PKW*

n

56

56

56

–

Age (year)

11.32 ± 1.08

11.41 ± 1.11

11.66 ± 1.08

0.27

BMI (kg/m2)

19.80 ± 4.50

20.66 ± 4.11

19.66 ± 4.48

0.22

HEI (score)

54.42 ± 10.69

54.20 ± 7.87

53.03 ± 11.82

0.53

MilkGroup (score)

5.06 ± 3.72

6.49 ± 3.34

5.10 ± 3.82

0.06

MeatGroup (score)

8.90 ± 2.51

9.30 ± 1.60

8.68 ± 2.45

0.54

Vitamin B12 levels (pmol/L)

227.04 ± 145.38

303.23 ± 101.07

396.26 ± 129.81

< 0.01

n

53

56

56

Folate levels (nmol/L)

11.26 ± 5.96

11.47 ± 4.55

10.76 ± 4.12

0.81

n

54

55

56

Pyridoxal levels (nmol/L)

7.81 ± 3.27

7.46 ± 2.58

9.36 ± 7.25

0.07

n

49

54

51

Riboflavin levels (nmol/L)

13.91 ± 11.43

13.26 ± 8.58

15.66 ± 10.30

0.16

n

49

47

51

tHcy levels (µmol/L)

2.85 ± 0.71

2.92 ± 0.90

2.50 ± 0.67

0.02

 

Categorical data (%)

PRS-T1

PRS-T2

PRS-T3

p-value Chi2/Fisher*

Socioeconomic status (%)

0.87

A1

–

–

–

A2

37.5

12.5

50.0

B1

31.8

40.9

27.3

B2

28.6

39.3

32.1

C1

33.3

31.2

35.4

C2

44.0

28.0

28.0

D

33.3

22.2

44.4

E

–

–

–

Sex (%) 0.94

0.94

Female

26.4

33.0

40.7

Male

41.6

33.8

24.7

  1. *p values were calculated by Kruskal–Wallis (PKW), Chi-square (PChi2) or Fisher test. Bold values denote p < 0.05. PRS-T: polygenic risk score tercile. A1 and A2: higher income. B1 and B2: medium income. C1, C2, D and E: lower income.
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