Table 2 Univariate and multivariate analyses associated with the overall survival (n = 411).
From: Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Sex | ||||
Female | Ref | |||
Male | 1.12 (0.772–1.625) | 0.55 | ||
Age (years) | ||||
< 70 | Ref | Ref | ||
≥ 70 | 2.261 (1.579–3.238) | < 0.001 | 2.623 (1.772–3.882) | < 0.001 |
ASA | ||||
1 | Ref | Ref | ||
2 | 1.793 (1.225–2.625) | 0.002 | 1.921 (1.280–2.883) | 0.001 |
3 and 4 | 1.153 (0.597–2.227) | 0.671 | 0.707 (0.352–1.417) | 0.328 |
No data | 1.145 (0.157–8.315) | 0.893 | 0.974 (0.126–7.495) | 0.980 |
BMI (kg/m2) | ||||
< 25 | Ref | Ref | ||
≥ 25 | 0.424 (0.253–0.708) | 0.001 | 0.431 (0.252–0.738) | 0.002 |
Preop-CEA (ng/mL) | ||||
< 5 | Ref | Ref | ||
≥ 5 | 1.793 (1.251–2.57) | 0.001 | 1.339 (0.910–1.972) | 0.138 |
Tumor location | ||||
Rt. colon | Ref | |||
Lt. colon | 0.927 (0.605–1.421) | 0.730 | ||
Rectum | 0.916 (0.571–1.471) | 0.719 | ||
Tumor size (cm) | ||||
< 5 | Ref | |||
≥ 5 | 1.516 (1.058–2.172) | 0.023 | ||
Histologic grade | ||||
G1 | Ref | |||
G2 | 1.514 (0.788–2.907) | 0.213 | ||
G3 | 1.711 (0.621–4.713) | 0.299 | ||
Etc | 1.485 (0.564–3.905) | 0.423 | ||
LVI | ||||
Absent | Ref | Ref | ||
Present | 2.078 (1.429–3.02) | < 0.001 | 1.602 (1.054–2.435) | 0.027 |
No data | 1.621 (0.590–4.45) | 0.348 | 1.485 (0.514–4.286) | 0.464 |
Number of retrieved LNs | ||||
< 12 | Ref | Ref | ||
≥ 12 | 0.628 (0.411–0.960) | 0.031 | 0.407 (0.259–0.639) | < 0.001 |
Stage | ||||
I and II | Ref | Ref | ||
III | 1.501 (0.983–2.291) | 0.059 | 2.056 (1.286–3.287) | 0.002 |
IV | 5.437 (3.401–8.692) | < 0.001 | 5.560 (3.216–9.610) | < 0.001 |
MSI | ||||
MSS/MSI-low | Ref | |||
MSI-high | 0.643 (0.280–1.479) | 0.300 | ||
No data | 0.962 (0.654–1.415) | 0.846 | ||
KRAS | ||||
Wild | Ref | |||
Mutant | 1.075 (0.565–2.041) | 0.826 | ||
No data | 1.336 (0.861–2.073) | 0.196 | ||
Chemotherapy | ||||
No | Ref | Ref | ||
Yes | 0.523 (0.365–0.750) | < 0.001 | 0.536 (0.357–0.805) | 0.002 |
NLR | ||||
< 3 | Ref | |||
≥ 3 | 1.432 (0.997–2.057) | 0.051 | ||
TLR | ||||
Continuous | 1.002 (0.934–1.073) | 0.965 | ||
BLR | ||||
Continuous | 4.638 (1.958–10.99) | < 0.001 | 5.279 (2.337–11.922) | < 0.001 |
SLR | ||||
Continuous | 2.686 (1.097–6.574) | 0.030 | ||
