Figure 4 | Scientific Reports

Figure 4

From: YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment

Figure 4

Impact of YIV906 and/or Anti-PD1 on macrophages and M1/M2 signature genes expression of Hepa 1–6 tumor. (A) Immunohistochemistry staining of F4/80 for macrophage infiltration into Hepa 1–6 tumor after 4-day treatments. (B) Quantification of macrophage of tumor sections after 4-day treatments. (C,D) MCP1 and iNOS protein expression of Hepa 1–6 tumor after 4-day treatments. (E) Heat map (significantly be up-regulated: red, significantly by down regulated: green) for indicating the mRNA expression determined by RT-qPCR following treatment at day 4. (F) Possibility of being M1 state based on the signature gene expression of (E). P values were obtained from T-test analysis. Details of experimental procedures are given in “Materials and methods”.

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