Figure 2 | Scientific Reports

Figure 2

From: Transcriptional drug repositioning and cheminformatics approach for differentiation therapy of leukaemia cells

Figure 2

Prospective validation of selected compounds on HL60 cell line. Among the compounds tested on the HL60 cell line fenbendazole (a) shows highest efficacy with LC50 values of 0.5 µM, 0.36 µM and 0.31 µM after 24, 48 and 72 h, respectively. The LC50 of Fenbendazole on BMSC cells was 5 µM (b). Genistein (c) was only minimally active (with LC50s of 12 µM after 48 h) while terazosin (d) and proxymetacaine (e) were inactive in HL60 cells. Fenbendazole exhibited 14.5-fold selectivity at 72 h over BMSC cells (f).

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