Table 1 Most relevant coexpression cliques of the clique map, their size and position, GO-term assignment, phenotype enrichment and tissue enrichment.

From: hsp-90 and unc-45 depletion induce characteristic transcriptional signatures in coexpression cliques of C. elegans

Clusternumber	Cluster name	Clique position	Best GO-term	log10(pvalue)_GO	Enrichment-Fold_GO	Best PEA-Term	log10(pvalue)_PEA	Enrichment-Fold_PEA	Best TEA-Term	log10(pvalue)_TEA	Enrichment-Fold_TEA
80	rps-14_21270-rps-11_20714	R4 C17	Structural constituent of ribosome GO:0003735	189.66	83.29	Pleiotropic defects severe early emb WBPhenotype:0,000,270	120.69	43.09	WBPaper00026980_intestine_enriched_WBbt_0005772_1970	1.44	1.28
211	srj-42-srw-113	R1 C1	Sensory perception GO:0007600	143.77	6.31	Dauer metabolism variant WBPhenotype:0,001,547	10.86	2.84	WBPaper00040420_FLP_enriched_WBbt_0006828_288	0.00	0.46
282	srj-21-srh-32	R1 C3	Intrinsic component of membrane GO:0031224	128.75	2.29	Dauer metabolism variant WBPhenotype:0,001,547	7.14	3.04	WBPaper00040420_FLP_enriched_WBbt_0006828_288	0.00	0.37
187	F45H10.2-R53.4_21676	R3 C4	Organelle Inner membrane GO:0019866	74.24	34.23	Avoids bacterial lawn WBPhenotype:0,000,402	27.00	6.57	WBPaper00026980_intestine_enriched_WBbt_0005772_1970	3.37	1.50
93	flp-5-F17C11.2	R4 C4	Neuropeptide signaling pathway GO:0007218	56.65	67.09	Sinusoidal movement variant WBPhenotype:0,004,018	22.79	11.85	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	22.28	3.93
90	ckr-1-T09B9.3	R1 C5	Intrinsic component of membrane GO:0031224	52.94	1.97	Sinusoidal movement variant WBPhenotype:0,004,018	8.60	3.85	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	53.78	4.32
42	rab-28-jbts-14_9542	R3 C5	Cell projection assembly GO:0030031	45.54	56.43	Amphid phasmid sensillum morphology variant WBPhenotype:0,001,527	16.40	17.48	WBPaper00037950_BAG-neuron_embryo_enriched_WBbt_0006825_454	42.10	7.48
203	sre-33-ZK1025.1_8337	R1 C2	Sensory perception GO:0007600	45.42	4.04	Dauer metabolism variant WBPhenotype:0,001,547	6.13	2.24	WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229	0.02	0.64
84	col-84-col-45	R9 C17	Collagen trimer GO:0005581	44.38	77.74	Dumpy WBPhenotype:0,000,583	3.04	8.11	WBPaper00040420_FLP_enriched_WBbt_0006828_288	0.00	0.20
41	col-117-col-167_1015	R9 C25	Structural constituent of cuticle GO:0042302	39.93	83.10	Dumpy WBPhenotype:0,000,583	5.47	7.68	WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974	0.00	0.33
233	his-46_959-his-64	R10 C26	DNA packaging complex GO:0044815	39.57	191.32	Sister chromatid segregation defective early emb WBPhenotype:0,000,772	26.48	94.19	WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974	0.00	0.07
215	col-138-col-49	R9 C23	Structural constituent of cuticle GO:0042302	35.30	87.06	Blistered WBPhenotype:0,000,025	5.77	41.59	WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229	0.07	0.60
80	rps-14_21270-rps-11_20714	R4 C17	Structural constituent of ribosome GO:0003735	189.66	83.29	Pleiotropic defects severe early emb WBPhenotype:0,000,270	120.69	43.09	WBPaper00026980_intestine_enriched_WBbt_0005772_1970	1.44	1.28
31	pbs-3_18439-rpn-5	R3 C7	Modification-dependent macromolecule catabolic process GO:0043632	23.08	13.30	Meiosis defective early emb WBPhenotype:0,001,041	32.03	23.37	WBPaper00031003_24hr_muscle_enriched_WBbt_0003675_918	2.78	1.65
187	F45H10.2-R53.4_21676	R3 C4	Organelle inner membrane GO:0019866	74.24	34.23	Avoids bacterial lawn WBPhenotype:0,000,402	27.00	6.57	WBPaper00026980_intestine_enriched_WBbt_0005772_1970	3.37	1.50
233	his-46_959-his-64	R10 C26	DNA packaging complex GO:0044815	39.57	191.32	Sister chromatid segregation defective early emb WBPhenotype:0,000,772	26.48	94.19	WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974	0.00	0.07
93	flp-5-F17C11.2	R4 C4	Neuropeptide signaling pathway GO:0007218	56.65	67.09	Sinusoidal movement variant WBPhenotype:0,004,018	22.79	11.85	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	22.28	3.93
2	rps-5_2365-rpl-15_1655	R10 C23	Structural constituent of ribosome GO:0003735	24.02	68.88	Pleiotropic defects severe early emb WBPhenotype:0,000,270	19.08	40.82	WBPaper00037950_PVD-OLL-neurons_larva_enriched_WBbt_0006831_878	0.00	0.23
143	his-20_965-his-4	R11 C22	DNA packaging complex GO:0044815	30.10	191.32	Sister chromatid segregation defective early emb WBPhenotype:0,000,772	18.37	87.98	WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329	0.00	0.18
96	mup-2-unc-87_284	R3 C13	Myofibril GO:0030016	31.32	27.72	Muscle system morphology variant WBPhenotype:0,000,603	17.34	8.57	WBPaper00031003_0hr_muscle_enriched_WBbt_0003675_761	20.71	3.64
218	H28G03.5_1027-H28G03.5_1042	R11 C24	Cell recognition GO:0008037	18.80	92.91	Axon fasciculation variant WBPhenotype:0,000,632	17.15	63.29	WBPaper00045521_Spermatogenic_WBbt_0005784_2743	0.00	0.33
42	rab-28-jbts-14_9542	R3 C5	Cell projection assembly GO:0030031	45.54	56.43	Amphid phasmid sensillum morphology variant WBPhenotype:0,001,527	16.40	17.48	WBPaper00037950_BAG-neuron_embryo_enriched_WBbt_0006825_454	42.10	7.48
234	pcn-1-cyb-3_17196	R7 C12	DNA replication GO:0006260	13.16	29.41	Cytokinesis variant WBPhenotype:0,002,408	16.17	11.19	WBPaper00037950_pharyngeal-muscle_embryo_enriched_WBbt_0005451_598	0.01	0.48
197	unc-11_429-unc-11_430	R12 C11	Phosphatidylinositol binding GO:0035091	15.76	172.19	Mid larval lethal WBPhenotype:0,000,116	15.12	160.50	WBPaper00037950_coelomocytes_embryo_enriched_WBbt_0005751_570	0.09	0.76
1	Y40H4A.2-ZK1053.2	R1 C6	Phosphorus metabolic process GO:0006793	17.12	3.03	Spermatogenesis variant WBPhenotype:0,000,670	1.48	4.25	WBPaper00045521_Spermatogenic_WBbt_0005784_2743	165.27	4.57
20	T22D1.5-inx-14	R2 C1	Embryo development GO:0009790	13.09	1.97	Aneuploidy WBPhenotype:0,001,882	11.50	6.39	WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974	73.49	5.82
273	C01G10.14-dct-9_3227	R2 C3	Regulation of cell shape GO:0008360	20.29	18.38	Spermatogenesis variant WBPhenotype:0,000,670	2.62	7.10	WBPaper00045521_Spermatogenic_WBbt_0005784_2743	71.95	3.62
111	mlt-9_22518-F33D4.6_14044	R2 C6	Cuticle development GO:0042335	16.79	11.64	Molt variant WBPhenotype:0,002,041	12.53	5.66	WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734	56.15	6.08
90	ckr-1-T09B9.3	R1 C5	Intrinsic component of membrane GO:0031224	52.94	1.97	Sinusoidal movement variant WBPhenotype:0,004,018	8.60	3.85	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	53.78	4.32
42	rab-28-jbts-14_9542	R3 C5	Cell projection assembly GO:0030031	45.54	56.43	Amphid phasmid sensillum morphology variant WBPhenotype:0,001,527	16.40	17.48	WBPaper00037950_BAG-neuron_embryo_enriched_WBbt_0006825_454	42.10	7.48
213	xbx-3-DH11.5_20397	R1 C12	Signaling GO:0023052	15.19	2.38	Backward point velocity increased WBPhenotype:0,002,325	7.12	8.29	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	41.49	4.53
155	F42A9.7-T22B3.3	R3 C11	Regulation of cell shape GO:0008360	9.67	17.73	Dauer metabolism variant WBPhenotype:0,001,547	1.51	2.28	WBPaper00045521_Spermatogenic_WBbt_0005784_2743	25.38	2.62
83	sol-1-jnk-1_18695	R1 C9	Nervous system development GO:0007399	21.52	4.87	Synapse morphology variant WBPhenotype:0,000,616	10.59	8.04	WBPaper00031532_Larva_Pan_Neuronal_Enriched_WBbt_0003679_1603	25.10	2.45
93	flp-5-F17C11.2	R4 C4	Neuropeptide signaling pathway GO:0007218	56.65	67.09	Sinusoidal movement variant WBPhenotype:0,004,018	22.79	11.85	WBPaper00037950_all-neurons_larva_enriched_WBbt_0003679_1013	22.28	3.93
96	mup-2-unc-87_284	R3 C13	Myofibril GO:0030016	31.32	27.72	Muscle system morphology variant WBPhenotype:0,000,603	17.34	8.57	WBPaper00031003_0hr_muscle_enriched_WBbt_0003675_761	20.71	3.64
34	dhs-28_22199-acs-14	R4 C9	Oxoacid metabolic process GO:0043436	14.25	9.18	Lipid metabolism variant WBPhenotype:0,000,725	4.43	3.34	WBPaper00037950_intestine_embryo_enriched_WBbt_0005772_886	20.41	3.78

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Table 1 Most relevant coexpression cliques of the clique map, their size and position, GO-term assignment, phenotype enrichment and tissue enrichment.

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