Table 3 Most strongly affected cliques by unc-45 RNAi and their characteristics.

From: hsp-90 and unc-45 depletion induce characteristic transcriptional signatures in coexpression cliques of C. elegans

Cluster name

Clique position

Best GO-Term

Best PEA-Term

Best TEA-Term

Mean STD

Log10(p) Exp 1

Log10(p) Exp 2

nspd-1-nspd-2

R12 C1

Structural constituent of cuticle GO:0042302

Dumpy WBPhenotype:0000583

WBPaper00037950_coelomocytes_embryo_enriched_WBbt_0005751_570

0.38 ± 0.12

4.41

1.84

msp-36-msp-55

R10 C19

Lipid storage GO:0019915

Linker cell migration variant WBPhenotype:0001511

WBPaper00040420_FLP_enriched_WBbt_0006828_288

0.35 ± 0.08

1.15

2.54

msp-63-msp-33

R9 C14

Lipid storage GO:0019915

Linker cell migration variant WBPhenotype:0001511

WBPaper00040420_FLP_enriched_WBbt_0006828_288

0.31 ± 0.09

7.92

9.08

hsp-16.2-F44E5.4_19238

R12 C4

Response to heat GO:0009408

Cadmium response variant WBPhenotype:0001653

WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229

0.29 ± 0.17

16.49

1.60

abu-7-abu-8_22491

R8 C26

Response to unfolded protein GO:0006986

Dauer constitutive WBPhenotype:0000012

WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329

0.25 ± 0.08

63.31

5.15

col-138-col-49

R9 C23

Structural constituent of cuticle GO:0042302

Blistered WBPhenotype:0000025

WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229

0.24 ± 0.22

34.90

0.93

col-117-col-167_1015

R9 C25

Structural constituent of cuticle GO:0042302

Dumpy WBPhenotype:0000583

WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974

0.24 ± 0.06

29.40

5.29

pqn-54-abu-9

R6 C11

Response to unfolded protein GO:0006986

Shortened life span WBPhenotype:0001171

WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329

0.2 ± 0.03

43.57

13.10

R12E2.14_75-R12E2.15

R6 C9

Structural constituent of cuticle GO:0042302

Dumpy WBPhenotype:0000583

WBPaper00037950_germline-precursors_embryo_enriched_WBbt_0006849_974

0.18 ± 0.08

47.12

8.99

lys-3-tsp-1

R11 C40

Carbohydrate metabolic process GO:0005975

Male nervous system development variant WBPhenotype:0001008

WBPaper00040420_ALM_PLM_enriched_WBbt_0005406_198

0.18 ± 0.22

27.93

1.06

C10C5.3-C10C5.5

R12 C40

Oxoacid metabolic process GO:0043436

Dauer constitutive WBPhenotype:0000012

WBPaper00037950_pharyngeal-muscle_embryo_enriched_WBbt_0005451_598

0.17 ± 0.05

4.43

2.28

F07A5.2-R10E9.2

R5 C7

Sodium ion transport GO:0006814

Nicotine response variant WBPhenotype:0001573

WBPaper00045521_Spermatogenic_WBbt_0005784_2743

0.15 ± 0.04

6.82

34.38

K11C4.1_20445-rnh-1.1

R8 C22

Regulation of cell shape GO:0008360

Fat content increased WBPhenotype:0001184

WBPaper00045521_Spermatogenic_WBbt_0005784_2743

0.14 ± 0.03

6.02

8.77

ssq-2_16507-ssq-3_1032

R12 C27

Response to hormone GO:0009725

Movement variant WBPhenotype:0001206

WBPaper00026980_intestine_enriched_WBbt_0005772_1970

0.13 ± 0

1.96

2.06

col-146-col-133

R9 C28

Structural constituent of cuticle GO:0042302

Dumpy WBPhenotype:0000583

WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229

0.12 ± 0.02

11.00

2.77

F42A9.7-T22B3.3

R3 C11

Regulation of cell shape GO:0008360

Dauer metabolism variant WBPhenotype:0001547

WBPaper00045521_Spermatogenic_WBbt_0005784_2743

0.11 ± 0.03

7.97

29.43

bus-8_3160-K04H4.2_2324

R9 C2

Amino sugar metabolic process GO:0006040

Molt variant WBPhenotype:0002041

WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329

0.11 ± 0.08

8.94

0.92

R12A1.3-M195.2

R6 C19

Amino sugar metabolic process GO:0006040

Dauer constitutive WBPhenotype:0000012

WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329

0.1 ± 0.04

6.65

3.63

T28A11.5-T06C12.14

R12 C14

Extracellular region GO:0005576

Dumpy WBPhenotype:0000583

WBPaper00037950_excretory-cell_larva_enriched_WBbt_0005812_528

0.1 ± 0.05

0.71

2.01

agmo-1_5527-F53B1.4

R10 C14

Pyridoxal phosphate binding GO:0030170

Molt variant WBPhenotype:0002041

WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734

0.1 ± 0.11

7.44

0.70

171971_x_at-D1054.11_184

R11 C37

Cell GO:0005623

Egg laying defective WBPhenotype:0000006

WBPaper00037950_hypodermis_larva_enriched_WBbt_0005733_1250

− 0.55 ± 0.09

3.70

0.66

gpd-3_977-aldo-1_21168

R9 C26

Glycosyl compound metabolic process GO:1901657

Fat content reduced WBPhenotype:0001183

WBPaper00031003_24hr_muscle_enriched_WBbt_0003675_918

− 0.51 ± 0.01

9.02

4.52

T05E12.6_12439-T05E12.6_12396

R10 C3

Lipid catabolic process GO:0016042

Transgene expression increased WBPhenotype:0001236

WBPaper00037950_pharyngeal-muscle_embryo_enriched_WBbt_0005451_598

− 0.29 ± 0.15

60.37

3.63

ZK1053.4-C08F1.6

R4 C16

Embryo development GO:0009790

Embryonic development variant WBPhenotype:0000749

WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734

− 0.26 ± 0.12

26.51

73.26

C46C2.5_15926-W03F11.1

R9 C22

Carbohydrate binding GO:0030246

Apoptosis increased WBPhenotype:0000183

WBPaper00037950_GABAergic-motor-neurons_embryo_enriched_WBbt_0005190_361

− 0.24 ± 0.02

8.57

10.00

ZC373.2-Y62H9A.6_1596

R3 C18

Flavonoid metabolic process GO:0009812

Cell membrane organization biogenesis variant WBPhenotype:0001982

WBPaper00037950_dopaminergic-neurons_larva_enriched_WBbt_0006746_1230

− 0.22 ± 0.03

46.68

19.54

nspc-1_614-nspc-10_22525

R10 C12

Extracellular region GO:0005576

Spermatogenesis variant WBPhenotype:0000670

WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229

− 0.21 ± 0.06

5.62

5.79

C46C2.5_15925-F17E9.2

R10 C8

Hydrolase activity—acting on glycosyl bonds GO:0016798

Embryonic development variant WBPhenotype:0000749

WBPaper00037950_coelomocytes_larva_enriched_WBbt_0005751_229

− 0.2 ± 0.01

6.65

6.25

C03B1.14-F46C3.2

R8 C21

Membrane GO:0016020

Chemical hypersensitive WBPhenotype:0001918

WBPaper00037950_intestine_larva_enriched_WBbt_0005772_946

− 0.19 ± 0

9.53

10.38

fbxc-28-sdz-28

R7 C8

Modification-dependent macromolecule catabolic process GO:0043632

L1 larval development variant WBPhenotype:0000751

WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734

− 0.18 ± 0.08

10.65

27.90

fbxb-13-fbxb-24

R8 C18

Protein oligomerization GO:0051259

Cholinergic agonist resistant WBPhenotype:0001578

WBPaper00024505_pharyngeal_enriched_WBbt_0003681_329

− 0.17 ± 0.1

1.20

13.08

dsh-1_3575-C40A11.4

R5 C17

Protein oligomerization GO:0051259

Ectopic expression transgene WBPhenotype:0001276

WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734

− 0.14 ± 0.07

2.78

9.72

vem-1-ugt-58

R12 C35

Oxoacid metabolic process GO:0043436

Epithelial cell physiology variant WBPhenotype:0000986

WBPaper00037950_BAG-neuron_embryo_enriched_WBbt_0006825_454

− 0.14 ± 0.01

2.03

0.89

sdz-10-fbxb-62

R3 C17

Glycosylation GO:0070085

L1 larval development variant WBPhenotype:0000751

WBPaper00037950_hypodermis_embryo_enriched_WBbt_0005733_734

− 0.14 ± 0.09

2.82

41.16

Y41D4B.17-K10D11.6

R12 C32

Immune system process GO:0002376

Exploded through vulva WBPhenotype:0000038

WBPaper00037950_intestine_larva_enriched_WBbt_0005772_946

− 0.12 ± 0.03

0.84

0.77

fbxb-31-fbxb-119

R11 C28

Embryo development GO:0009790

Transgene expression reduced WBPhenotype:0001278

WBPaper00040420_FLP_enriched_WBbt_0006828_288

− 0.12 ± 0.09

0.64

4.30

R03E1.2_7363-ucr-2.1

R10 C30

Mitochondrion GO:0005739

mRNA levels increased WBPhenotype:0000136

WBPaper00037950_excretory-cell_larva_enriched_WBbt_0005812_528

− 0.12 ± 0.03

0.98

2.14

C35C5.8_15869-best-1

R10 C21

Transmembrane transport GO:0055085

Fat content increased WBPhenotype:0001184

WBPaper00037950_excretory-cell_larva_enriched_WBbt_0005812_528

− 0.12 ± 0.03

4.11

1.04

pek-1_22220-pek-1_33

R11 C12

Aging GO:0007568

Sluggish WBPhenotype:0000646

WBPaper00037950_GABAergic-motor-neurons_embryo_enriched_WBbt_0005190_361

− 0.11 ± 0

1.85

1.69

iff-2_18754-rpl-25.1

R12 C37

Amide biosynthetic process GO:0043604

Hermaphrodite fertility reduced WBPhenotype:0001259

WBPaper00037950_PVD-OLL-neurons_larva_enriched_WBbt_0006831_878

− 0.11 ± 0.03

0.65

1.39

  1. Clique positions (letter = row, number = position from left to right) correspond to the clique map shown in Fig. 2b.
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